Indianapolis Colts safety Melvin Bullitt, Bob Sanders' replacement and the team's special teams captain, is out for the season after breaking a bone in his right shoulder Sunday in Jacksonville, a league source told ESPN NFL Insider Adam Schefter.
Bullitt will have surgery in two weeks and be placed on injured reserve.
Sanders already is nursing a biceps injury that will sideline him into December, if not for the season.
The Colts are 2-2 after Sunday's loss and 0-2 in the AFC South for the first time ever, and injuries -- beside the ones to Bullitt and Sanders -- have been a big problem for Indianapolis this season.
Receiver Pierre Garcon has missed two games with a bad hamstring. Receiver Anthony Gonzalez has missed three games with a sprained right ankle. Left tackle Charlie Johnson was slowed during the season's first month by a sprained right foot, and Pro Bowl center Jeff Saturday has been playing his way back from August knee surgery.
Information from The Associated Press was used in this report.